00949nas a2200241   4500000000100000000000100001008004100002260001200043653001800055653001300073653001900086653001800105653001500123100001700138700002100155700001600176245005500192856004400247300001200291490000700303520038300310022001400693       2015                            d  c2015-0410adisease model10aDiseases10aDrug Discovery10aLab-on-a-chip10aToxicology1 aEric W. Esch1 aAnthony Bahinski1 aDongeun Huh00aOrgans-on-chips at the frontiers of drug discovery  uhttps://www.nature.com/articles/nrd4539  a248-2600 v143 aMicroengineered cell culture systems are becoming sufficiently sophisticated that they can recapitulate many of the phenomena observed in tissues and organisms. Here, Huh and colleagues discuss the advances made in these 'organs-on-chips' and how they could be used in drug development, including target identification and validation, toxicity screening and stratified medicine.  a1474-1784