01240nas a2200217   4500000000100000000000100001008004100002260001500043653002800058653001100086653002600097653001400123100002500137700002100162700001600183245002400199300001200223490000800235520076500243022001401008       2019                            d  c2019-06-0710aCell Culture Techniques10aHumans10aLab-On-A-Chip Devices10aorganoids1 aSunghee Estelle Park1 aAndrei Georgescu1 aDongeun Huh00aOrganoids-on-a-chip  a960-9650 v3643 aRecent studies have demonstrated an array of stem cell-derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for the production, control, and analysis of organoids and their microenvironment. In this Review, we explore organ-on-a-chip technology as a platform to fulfill this need and examine how this technology may be leveraged to address major technical challenges in organoid research. We also discuss emerging opportunities and future obstacles for the development and application of organoid-on-a-chip technology.  a1095-9203