01614nas a2200373   4500000000100000000000100001008004100002260001200043653001200055653001100067653001800078653002900096653001300125653001900138653003400157653001200191653001800203653003000221653002000251653002100271653001000292100001500302700002200317700001600339700002800355700002500383700002100408700002100429245003900450300001200489490000700501520071800508022001401226       2020                            d  c2020-1110aAnimals10aHumans10amicrofluidics10aOrgan Culture Techniques10aVirology10aVirus Diseases10aVirus Physiological Phenomena10aViruses10amicrofluidics10amicrophysiological system10aorgan-on-a-chip10aviral infections10avirus1 aHuaqi Tang1 aYasmine Abouleila1 aLonglong Si1 aAna Maria Ortega-Prieto1 aChristine L. Mummery1 aDonald E. Ingber1 aAlireza Mashaghi00aHuman Organs-on-Chips for Virology  a934-9460 v283 aWhile conventional in vitro culture systems and animal models have been used to study the pathogenesis of viral infections and to facilitate development of vaccines and therapeutics for viral diseases, models that can accurately recapitulate human responses to infection are still lacking. Human organ-on-a-chip (Organ Chip) microfluidic culture devices that recapitulate tissue-tissue interfaces, fluid flows, mechanical cues, and organ-level physiology have been developed to narrow the gap between in vitro experimental models and human pathophysiology. Here, we describe how recent developments in Organ Chips have enabled re-creation of complex pathophysiological features of human viral infections in vitro.  a1878-4380