02123nas a2200373   4500000000100000000000100001008004100002260001200043653001300055653002200068653003100090653001300121100001800134700001200152700001800164700001300182700001200195700001300207700002200220700001600242700001600258700001900274700001400293700001800307700001700325700002200342700001200364245005700376856005500433300001200488490000600500520122900506022001401735       2020                            d  c2020-1110aDiseases10aMaterials science10aNanoscience and technology10aVirology1 aZhongmin Tang1 aNa Kong1 aXingcai Zhang1 aYuan Liu1 aPing Hu1 aShan Mou1 aPeter Liljeström1 aJianlin Shi1 aWeihong Tan1 aJong Seung Kim1 aYihai Cao1 aRobert Langer1 aKam W. Leong1 aOmid C. Farokhzad1 aWei Tao00aA materials-science perspective on tackling COVID-19  uhttps://www.nature.com/articles/s41578-020-00247-y  a847-8600 v53 aThe ongoing SARS-CoV-2 pandemic highlights the importance of materials science in providing tools and technologies for antiviral research and treatment development. In this Review, we discuss previous efforts in materials science in developing imaging systems and microfluidic devices for the in-depth and real-time investigation of viral structures and transmission, as well as material platforms for the detection of viruses and the delivery of antiviral drugs and vaccines. We highlight the contribution of materials science to the manufacturing of personal protective equipment and to the design of simple, accurate and low-cost virus-detection devices. We then investigate future possibilities of materials science in antiviral research and treatment development, examining the role of materials in antiviral-drug design, including the importance of synthetic material platforms for organoids and organs-on-a-chip, in drug delivery and vaccination, and for the production of medical equipment. Materials-science-based technologies not only contribute to the ongoing SARS-CoV-2 research efforts but can also provide platforms and tools for the understanding, protection, detection and treatment of future viral diseases.  a2058-8437