01080nas a2200217   4500000000100000000000100001008004100002260001200043653003500055653001500090653002800105100001800133700001700151700002000168245008500188856005500273300001200328490000700340520050100347022001400848       2021                            d  c2021-0810ainduced pluripotent stem cells10aSARS-CoV-210aStem-cell biotechnology1 aKevin G. Chen1 aKyeyoon Park1 aJason R. Spence00aStudying SARS-CoV-2 infectivity and therapeutic responses with complex organoids  uhttps://www.nature.com/articles/s41556-021-00721-x  a822-8330 v233 aClinical management of patients with severe complications of COVID-19 has been hindered by a lack of effective drugs and a failure to capture the extensive heterogeneity of the disease with conventional methods. Here we review the emerging roles of complex organoids in the study of SARS-CoV-2 infection, modelling of COVID-19 disease pathology and in drug, antibody and vaccine development. We discuss opportunities for COVID-19 research and remaining challenges in the application of organoids.  a1476-4679