01269nas a2200301   4500000000100000000000100001008004100002260001500043653001900058653002200077653001700099653001500116653001100131653002600142653002400168653002000192653002200212653002300234653002300257653001400280100001800294700001800312245005400330300000800384490000700392520055400399022001400953       2022                            d  c2022-08-2010abody-on-a-chip10aDisease modelling10adrug testing10aHuman Body10aHumans10aLab-On-A-Chip Devices10aMicrofluidic device10aorgan-on-a-chip10aPatient-on-a-chip10aPrecision Medicine10aPrecision Medicine10aStem cell1 aZhong Alan Li1 aRocky S. Tuan00aTowards establishing human body-on-a-chip systems  a4310 v133 aBody-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically linked OoCs. Herein, the major innovations in their BoC system are discussed, followed by our future perspectives on enhancing the physiological relevance and scalability of BoCs for applications in studying disease mechanisms, testing potential therapeutics, and developing personalized medicine.  a1757-6512