01388nas a2200229   4500000000100000000000100001008004100002260001200043653002600055653002700081100002100108700001900129700002000148700002300168700001500191245004700206856005500253300001400308490000700322520081500329022001401144       2022                            d  c2022-1210aMechanisms of disease10atranslational research1 aJennifer E. Rood1 aAidan Maartens1 aAnna Hupalowska1 aSarah A. Teichmann1 aAviv Regev00aImpact of the Human Cell Atlas on medicine  uhttps://www.nature.com/articles/s41591-022-02104-7  a2486-24960 v283 aSingle-cell atlases promise to provide a ‘missing link’ between genes, diseases and therapies. By identifying the specific cell types, states, programs and contexts where disease-implicated genes act, we will understand the mechanisms of disease at the cellular and tissue levels and can use this understanding to develop powerful disease diagnostics; identify promising new drug targets; predict their efficacy, toxicity and resistance mechanisms; and empower new kinds of therapies, from cancer therapies to regenerative medicine. Here, we lay out a vision for the potential of cell atlases to impact the future of medicine, and describe how advances over the past decade have begun to realize this potential in common complex diseases, infectious diseases (including COVID-19), rare diseases and cancer.  a1546-170X