01294nas a2200217   4500000000100000008004100001260001200042653002200054653002000076653001900096653003000115653001500145100001600160700002100176245007500197856007100272300001200343490000700355520070000362022001401062       2022                            d  c2022-0910a3-D tissue models10alung physiology10amechanobiology10amicrophysiological system10aorgan chip1 aHaiqing Bai1 aDonald E. Ingber00aWhat Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?  uhttps://journals.physiology.org/doi/abs/10.1152/physiol.00012.2022  a242-2520 v373 aThe intertwined relationship between structure and function has been key to understanding human organ physiology and disease pathogenesis. An organ-on-a-chip (organ chip) is a bioengineered microfluidic cell culture device lined by living cells and tissues that recapitulates organ-level functions in vitro. This is accomplished by recreating organ-specific tissue-tissue interfaces and microenvironmental biochemical and mechanical cues while providing dynamic perfusion through endothelium-lined vascular channels. In this review, we discuss how this emerging technology has contributed to the understanding of human lung structure-function relationships at the cell, tissue, and organ levels.  a1548-9213