@article{5396,
  keywords = {Animals, Female, Hormones, Humans, Hydrogels, Ovariectomy, Ovary, Rats, Spheroids, Cellular},
  author = {Hyo-Jin Yoon and Yong Jae Lee and Sewoom Baek and Young Shin Chung and Dae-Hyun Kim and Jae Hoon Lee and Yong Cheol Shin and Young Min Shin and Chungsoon Ryu and Hye-Seon Kim and So Hyun Ahn and Heeyon Kim and Young Bin Won and Inha Lee and Myung Jae Jeon and Si Hyun Cho and Byung Seok Lee and Hak-Joon Sung and Young Sik Choi},
  title = {Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions},
  abstract = {The regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. The VHOS implantation effectively suppresses the side effects observed with synthetic hormone treatment (i.e., tissue overgrowth, hyperplasia, cancer progression, deep vein thrombosis) to the normal levels, while effectively preventing the representative aftereffects of menopause (i.e., gaining fatty weight, inducing osteoporosis). These results highlight the unprecedented therapeutic potential of an implantable VHOS against menopause and suggest that it may be used as an alternative approach to standard hormone therapy.},
  year = {2021},
  journal = {Science Advances},
  volume = {7},
  pages = {eabe8873},
  month = {2021-04},
  issn = {2375-2548},
  doi = {10.1126/sciadv.abe8873},
  language = {eng},
}