@article{5381,
  keywords = {Animals, Female, Humans, Menstrual Cycle, Mesothelin, Mice, Microfluidic Analytical Techniques, Ovary, Pregnancy, Tissue Culture Techniques},
  author = {Shuo Xiao and Jonathan R. Coppeta and Hunter B. Rogers and Brett C. Isenberg and Jie Zhu and Susan A. Olalekan and Kelly E. McKinnon and Danijela Dokic and Alexandra S. Rashedi and Daniel J. Haisenleder and Saurabh S. Malpani and Chanel A. Arnold-Murray and Kuanwei Chen and Mingyang Jiang and Lu Bai and Catherine T. Nguyen and Jiyang Zhang and Monica M. Laronda and Thomas J. Hope and Kruti P. Maniar and Mary Ellen Pavone and Michael J. Avram and Elizabeth C. Sefton and Spiro Getsios and Joanna E. Burdette and J. Julie Kim and Jeffrey T. Borenstein and Teresa K. Woodruff},
  title = {A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle},
  abstract = {The endocrine system dynamically controls tissue differentiation and homeostasis, but has not been studied using dynamic tissue culture paradigms. Here we show that a microfluidic system supports murine ovarian follicles to produce the human 28-day menstrual cycle hormone profile, which controls human female reproductive tract and peripheral tissue dynamics in single, dual and multiple unit microfluidic platforms (Solo-MFP, Duet-MFP and Quintet-MPF, respectively). These systems simulate the in vivo female reproductive tract and the endocrine loops between organ modules for the ovary, fallopian tube, uterus, cervix and liver, with a sustained circulating flow between all tissues. The reproductive tract tissues and peripheral organs integrated into a microfluidic platform, termed EVATAR, represents a powerful new in vitro tool that allows organ-organ integration of hormonal signalling as a phenocopy of menstrual cycle and pregnancy-like endocrine loops and has great potential to be used in drug discovery and toxicology studies.},
  year = {2017},
  journal = {Nature Communications},
  volume = {8},
  pages = {14584},
  month = {2017-03-28},
  issn = {2041-1723},
  doi = {10.1038/ncomms14584},
  language = {eng},
}