@article{4941,
  keywords = {Alzheimer's disease, Cellular neuroscience, Epigenomics, Gene expression},
  author = {Mariano I. Gabitto and Kyle J. Travaglini and Victoria M. Rachleff and Eitan S. Kaplan and Brian Long and Jeanelle Ariza and Yi Ding and Joseph T. Mahoney and Nick Dee and Jeff Goldy and Erica J. Melief and Anamika Agrawal and Omar Kana and Xingjian Zhen and Samuel T. Barlow and Krissy Brouner and Jazmin Campos and John Campos and Ambrose J. Carr and Tamara Casper and Rushil Chakrabarty and Michael Clark and Jonah Cool and Rachel Dalley and Martin Darvas and Song-Lin Ding and Tim Dolbeare and Tom Egdorf and Luke Esposito and Rebecca Ferrer and Lynn E. Fleckenstein and Rohan Gala and Amanda Gary and Emily Gelfand and Jessica Gloe and Nathan Guilford and Junitta Guzman and Daniel Hirschstein and Windy Ho and Madison Hupp and Tim Jarsky and Nelson Johansen and Brian E. Kalmbach and Lisa M. Keene and Sarah Khawand and Mitchell D. Kilgore and Amanda Kirkland and Michael Kunst and Brian R. Lee and Mckaila Leytze and Christine L. Mac Donald and Jocelin Malone and Zoe Maltzer and Naomi Martin and Rachel McCue and Delissa McMillen and Gonzalo Mena and Emma Meyerdierks and Kelly P. Meyers and Tyler Mollenkopf and Mark Montine and Amber L. Nolan and Julie K. Nyhus and Paul A. Olsen and Maiya Pacleb and Chelsea M. Pagan and Nicholas Peña and Trangthanh Pham and Christina Alice Pom and Nadia Postupna and Christine Rimorin and Augustin Ruiz and Giuseppe A. Saldi and Aimee M. Schantz and Nadiya V. Shapovalova and Staci A. Sorensen and Brian Staats and Matt Sullivan and Susan M. Sunkin and Carol Thompson and Michael Tieu and Jonathan T. Ting and Amy Torkelson and Tracy Tran and Nasmil J. Valera Cuevas and Sarah Walling-Bell and Ming-Qiang Wang and Jack Waters and Angela M. Wilson and Ming Xiao and David Haynor and Nicole M. Gatto and Suman Jayadev and Shoaib Mufti and Lydia Ng and Shubhabrata Mukherjee and Paul K. Crane and Caitlin S. Latimer and Boaz P. Levi and Kimberly A. Smith and Jennie L. Close and Jeremy A. Miller and Rebecca D. Hodge and Eric B. Larson and Thomas J. Grabowski and Michael Hawrylycz and C. Dirk Keene and Ed S. Lein},
  title = {Integrated multimodal cell atlas of Alzheimer’s disease},
  abstract = {Alzheimer’s disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with varying AD pathologies. This cohort includes 33 male donors and 51 female donors, with an average age at time of death of 88 years. We used quantitative neuropathology to place donors along a disease pseudoprogression score. Pseudoprogression analysis revealed two disease phases: an early phase with a slow increase in pathology, presence of inflammatory microglia, reactive astrocytes, loss of somatostatin+ inhibitory neurons, and a remyelination response by oligodendrocyte precursor cells; and a later phase with exponential increase in pathology, loss of excitatory neurons and Pvalb+ and Vip+ inhibitory neuron subtypes. These findings were replicated in other major AD studies.},
  year = {2024},
  journal = {Nature Neuroscience},
  volume = {27},
  pages = {2366-2383},
  month = {2024-12},
  issn = {1546-1726},
  url = {https://www.nature.com/articles/s41593-024-01774-5},
  doi = {10.1038/s41593-024-01774-5},
  language = {en},
}