@article{4671,
  keywords = {RNA sequencing, Transcriptomics},
  author = {Magda Marečková and Luz Garcia-Alonso and Marie Moullet and Valentina Lorenzi and Robert Petryszak and Carmen Sancho-Serra and Agnes Oszlanczi and Cecilia Icoresi Mazzeo and Frederick C. K. Wong and Iva Kelava and Sophie Hoffman and Michał Krassowski and Kurtis Garbutt and Kezia Gaitskell and Slaveya Yancheva and Ee Von Woon and Victoria Male and Ingrid Granne and Karin Hellner and Krishnaa T. Mahbubani and Kourosh Saeb-Parsy and Mohammad Lotfollahi and Elena Prigmore and Jennifer Southcombe and Rebecca A. Dragovic and Christian M. Becker and Krina T. Zondervan and Roser Vento-Tormo},
  title = {An integrated single-cell reference atlas of the human endometrium},
  abstract = {The complex and dynamic cellular composition of the human endometrium remains poorly understood. Previous endometrial single-cell atlases profiled few donors and lacked consensus in defining cell types. We introduce the Human Endometrial Cell Atlas (HECA), a high-resolution single-cell reference atlas (313,527 cells) combining published and new endometrial single-cell transcriptomics datasets of 63 women with and without endometriosis. HECA assigns consensus and identifies previously unreported cell types, mapped in situ using spatial transcriptomics and validated using a new independent single-nuclei dataset (312,246 nuclei, 63 donors). In the functionalis, we identify intricate stromal–epithelial cell coordination via transforming growth factor beta (TGFβ) signaling. In the basalis, we define signaling between fibroblasts and an epithelial population expressing progenitor markers. Integration of HECA with large-scale endometriosis genome-wide association study data pinpoints decidualized stromal cells and macrophages as most likely dysregulated in endometriosis. The HECA is a valuable resource for studying endometrial physiology and disorders, and for guiding microphysiological in vitro systems development.},
  year = {2024},
  journal = {Nature Genetics},
  volume = {56},
  pages = {1925-1937},
  month = {2024-09},
  issn = {1546-1718},
  url = {https://www.nature.com/articles/s41588-024-01873-w},
  doi = {10.1038/s41588-024-01873-w},
  language = {en},
}