@misc{431,
  author = {Valerie Zuang and João Barroso and Elisabet Berggren and Stephanie Bopp and Sara Bridio and Silvia Casati and Raffaella Corvi and Pierre Deceuninck and Antonio Franco and Annalisa Gastaldello and Ingrid Langezaal and Julia Malinowska and Milena Mennecozzi and Anne Milcamps and Sharon Munn and Monica Piergiovanni and Pilar Prieto-Peraita and Stavroula Sampani and Debora Valsesia and Maurice Whelan and Clemens Wittwehr and Andrew Worth},
  title = {Non-Animal Methods in Science and Regulation},
  abstract = {The 2023 EURL ECVAM Status Report outlines research and development activities, along with initiatives that foster the implementation and utilisation of non-animal methods and approaches in scientific research and regulation. The Three Rs principle, which advocates for Replacement, Reduction, and Refinement of animal use in basic, applied, and translational research, as well as for regulatory purposes, is firmly established in EU legislation, with the ultimate goal of fully replacing animal testing.
New approach methodologies encompassing a range of innovative technologies, including in vitro methods employing 3D tissues and cells, organ-on-chip technologies, computational models (including machine learning and artificial intelligence), and 'omics (transcriptomics and metabolomics), are developed, evaluated, and integrated into assessment frameworks in order to enhance the efficiency and effectiveness of hazard and risk assessment of chemicals and products across various regulatory contexts. Furthermore, substantial efforts are directed at promoting the development and utilisation of non-animal approaches in fundamental and applied research, where the majority of animal testing occurs, as well as for educational purposes. The achievements and accomplishments documented in this report are the culmination of collaborative efforts with EURL ECVAM's dedicated partners and stakeholders.},
  year = {2024},
  month = {2024/03/12},
  publisher = {European Union},
  address = {Luxembourg},
  issn = {JRC136460},
  url = {https://publications.jrc.ec.europa.eu/repository/handle/JRC136460},
  language = {en},
}