@article{4081, keywords = {BBB-on-a-chip, Blood–brain barrier, microfluidics, Neurovascular unit, Stroke}, author = {Nienke R. Wevers and Arya Lekshmi Nair and Tania M. Fowke and Maria Pontier and Dhanesh G. Kasi and Xandor M. Spijkers and Charlie Hallard and Gwenaëlle Rabussier and Remko van Vught and Paul Vulto and Helga E. de Vries and Henriëtte L. Lanz}, title = {Modeling ischemic stroke in a triculture neurovascular unit on-a-chip}, abstract = {In ischemic stroke, the function of the cerebral vasculature is impaired. This vascular structure is formed by the so-called neurovascular unit (NVU). A better understanding of the mechanisms involved in NVU dysfunction and recovery may lead to new insights for the development of highly sought therapeutic approaches. To date, there remains an unmet need for complex human in vitro models of the NVU to study ischemic events seen in the human brain.}, year = {2021}, journal = {Fluids and Barriers of the CNS}, volume = {18}, pages = {59}, month = {2021-12-14}, issn = {2045-8118}, url = {https://doi.org/10.1186/s12987-021-00294-9}, doi = {10.1186/s12987-021-00294-9}, }