@article{4041,
  author = {Alexander Shapson-Coe and Michał Januszewski and Daniel R. Berger and Art Pope and Yuelong Wu and Tim Blakely and Richard L. Schalek and Peter H. Li and Shuohong Wang and Jeremy Maitin-Shepard and Neha Karlupia and Sven Dorkenwald and Evelina Sjostedt and Laramie Leavitt and Dongil Lee and Jakob Troidl and Forrest Collman and Luke Bailey and Angerica Fitzmaurice and Rohin Kar and Benjamin Field and Hank Wu and Julian Wagner-Carena and David Aley and Joanna Lau and Zudi Lin and Donglai Wei and Hanspeter Pfister and Adi Peleg and Viren Jain and Jeff W. Lichtman},
  title = {A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution},
  abstract = {To fully understand how the human brain works, knowledge of its structure at high resolution is needed. Presented here is a computationally intensive reconstruction of the ultrastructure of a cubic millimeter of human temporal cortex that was surgically removed to gain access to an underlying epileptic focus. It contains about 57,000 cells, about 230 millimeters of blood vessels, and about 150 million synapses and comprises 1.4 petabytes. Our analysis showed that glia outnumber neurons 2:1, oligodendrocytes were the most common cell, deep layer excitatory neurons could be classified on the basis of dendritic orientation, and among thousands of weak connections to each neuron, there exist rare powerful axonal inputs of up to 50 synapses. Further studies using this resource may bring valuable insights into the mysteries of the human brain.},
  year = {2024},
  journal = {Science},
  volume = {384},
  pages = {eadk4858},
  month = {2024-05-10},
  url = {https://www.science.org/doi/10.1126/science.adk4858},
  doi = {10.1126/science.adk4858},
}