@article{4021, author = {Eric Courchesne and Vani Taluja and Sanaz Nazari and Caitlin M. Aamodt and Karen Pierce and Kuaikuai Duan and Sunny Stophaeros and Linda Lopez and Cynthia Carter Barnes and Jaden Troxel and Kathleen Campbell and Tianyun Wang and Kendra Hoekzema and Evan E. Eichler and Joao V. Nani and Wirla Pontes and Sandra Sanchez Sanchez and Michael V. Lombardo and Janaina S. de Souza and Mirian A. F. Hayashi and Alysson R. Muotri}, title = {Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms}, abstract = {Social affective and communication symptoms are central to autism spectrum disorder (ASD), yet their severity differs across toddlers: Some toddlers with ASD display improving abilities across early ages and develop good social and language skills, while others with “profound” autism have persistently low social, language and cognitive skills and require lifelong care. The biological origins of these opposite ASD social severity subtypes and developmental trajectories are not known.}, year = {2024}, journal = {Molecular Autism}, volume = {15}, pages = {22}, month = {2024-05-25}, issn = {2040-2392}, url = {https://doi.org/10.1186/s13229-024-00602-8}, doi = {10.1186/s13229-024-00602-8}, }