@article{3516,
  keywords = {B-Lymphocytes, Epithelial Cells, Humans, Immunoglobulin A, Lung, Respiratory Mucosa},
  author = {Elo Madissoon and Amanda J. Oliver and Vitalii Kleshchevnikov and Anna Wilbrey-Clark and Krzysztof Polanski and Nathan Richoz and Ana Ribeiro Orsi and Lira Mamanova and Liam Bolt and Rasa Elmentaite and J. Patrick Pett and Ni Huang and Chuan Xu and Peng He and Monika Dabrowska and Sophie Pritchard and Liz Tuck and Elena Prigmore and Shani Perera and Andrew Knights and Agnes Oszlanczi and Adam Hunter and Sara F. Vieira and Minal Patel and Rik G. H. Lindeboom and Lia S. Campos and Kazuhiko Matsuo and Takashi Nakayama and Masahiro Yoshida and Kaylee B. Worlock and Marko Z. Nikolić and Nikitas Georgakopoulos and Krishnaa T. Mahbubani and Kourosh Saeb-Parsy and Omer Ali Bayraktar and Menna R. Clatworthy and Oliver Stegle and Natsuhiko Kumasaka and Sarah A. Teichmann and Kerstin B. Meyer},
  title = {A spatially resolved atlas of the human lung characterizes a gland-associated immune niche},
  abstract = {Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the human lung, but their spatial context is less well defined. To (re)define tissue architecture of lung and airways, we profiled five proximal-to-distal locations of healthy human lungs in depth using multi-omic single cell/nuclei and spatial transcriptomics (queryable at lungcellatlas.org ). Using computational data integration and analysis, we extend beyond the suspension cell paradigm and discover macro and micro-anatomical tissue compartments including previously unannotated cell types in the epithelial, vascular, stromal and nerve bundle micro-environments. We identify and implicate peribronchial fibroblasts in lung disease. Importantly, we discover and validate a survival niche for IgA plasma cells in the airway submucosal glands (SMG). We show that gland epithelial cells recruit B cells and IgA plasma cells, and promote longevity and antibody secretion locally through expression of CCL28, APRIL and IL-6. This new 'gland-associated immune niche' has implications for respiratory health.},
  year = {2023},
  journal = {Nature Genetics},
  volume = {55},
  pages = {66-77},
  month = {2023-01},
  issn = {1546-1718},
  doi = {10.1038/s41588-022-01243-4},
  language = {eng},
}