@article{3421,
  author = {Louise A. Huuki-Myers and Abby Spangler and Nicholas J. Eagles and Kelsey D. Montgomery and Sang Ho Kwon and Boyi Guo and Melissa Grant-Peters and Heena R. Divecha and Madhavi Tippani and Chaichontat Sriworarat and Annie B. Nguyen and Prashanthi Ravichandran and Matthew N. Tran and Arta Seyedian and PsychENCODE Consortium and Thomas M. Hyde and Joel E. Kleinman and Alexis Battle and Stephanie C. Page and Mina Ryten and Stephanie C. Hicks and Keri Martinowich and Leonardo Collado-Torres and Kristen R. Maynard},
  title = {A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex},
  abstract = {The molecular organization of the human neocortex historically has been studied in the context of its histological layers. However, emerging spatial transcriptomic technologies have enabled unbiased identification of transcriptionally defined spatial domains that move beyond classic cytoarchitecture. We used the Visium spatial gene expression platform to generate a data-driven molecular neuroanatomical atlas across the anterior-posterior axis of the human dorsolateral prefrontal cortex. Integration with paired single-nucleus RNA-sequencing data revealed distinct cell type compositions and cell-cell interactions across spatial domains. Using PsychENCODE and publicly available data, we mapped the enrichment of cell types and genes associated with neuropsychiatric disorders to discrete spatial domains.},
  year = {2024},
  journal = {Science},
  volume = {384},
  pages = {eadh1938},
  month = {2024-05-24},
  url = {https://www.science.org/doi/10.1126/science.adh1938},
  doi = {10.1126/science.adh1938},
}