@article{3236,
  keywords = {Cancer treatment, Cancers and neoplasms, Drug research and development, Metaanalysis, Research errors, Research reporting guidelines, Rodents, Simulation and modeling},
  author = {Constance Holman and Sophie K. Piper and Ulrike Grittner and Andreas Antonios Diamantaras and Jonathan Kimmelman and Bob Siegerink and Ulrich Dirnagl},
  title = {Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke},
  abstract = {Given small sample sizes, loss of animals in preclinical experiments can dramatically alter results. However, effects of attrition on distortion of results are unknown. We used a simulation study to analyze the effects of random and biased attrition. As expected, random loss of samples decreased statistical power, but biased removal, including that of outliers, dramatically increased probability of false positive results. Next, we performed a meta-analysis of animal reporting and attrition in stroke and cancer. Most papers did not adequately report attrition, and extrapolating from the results of the simulation data, we suggest that their effect sizes were likely overestimated.},
  year = {0},
  journal = {PLOS Biology},
  volume = {14},
  pages = {e1002331},
  month = {Jan 4, 2016},
  issn = {1545-7885},
  url = {https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002331},
  doi = {10.1371/journal.pbio.1002331},
  language = {en},
}