@article{1986,
  keywords = {Acute systemic toxicity, animal alternatives, hazard classification and risk assessment, lethality testing, Regulatory toxicology},
  author = {Judy Strickland and Esther Haugabrooks and David G. Allen and Luciene B. Balottin and Yoko Hirabayashi and Nicole C. Kleinstreuer and Hajime Kojima and Claudio Nishizawa and Pilar Prieto and Deborah E. Ratzlaff and Jayoung Jeong and JinHee Lee and Ying Yang and Pinpin Lin and Kristie Sullivan and Warren Casey},
  title = {International regulatory uses of acute systemic toxicity data and integration of new approach methodologies},
  abstract = {Chemical regulatory authorities around the world require systemic toxicity data from acute exposures via the oral, dermal, and inhalation routes for human health risk assessment. To identify opportunities for regulatory uses of non-animal replacements for these tests, we reviewed acute systemic toxicity testing requirements for jurisdictions that participate in the International Cooperation on Alternative Test Methods (ICATM): Brazil, Canada, China, the European Union, Japan, South Korea, Taiwan, and the USA. The chemical sectors included in our review of each jurisdiction were cosmetics, consumer products, industrial chemicals, pharmaceuticals, medical devices, and pesticides. We found acute systemic toxicity data were most often required for hazard assessment, classification, and labeling, and to a lesser extent quantitative risk assessment. Where animal methods were required, animal reduction methods were typically recommended. For many jurisdictions and chemical sectors, non-animal alternatives are not accepted, but several jurisdictions provide guidance to support the use of test waivers to reduce animal use for specific applications. An understanding of international regulatory requirements for acute systemic toxicity testing will inform ICATM’s strategy for the development, acceptance, and implementation of non-animal alternatives to assess the health hazards and risks associated with acute toxicity.},
  year = {2023},
  journal = {Critical Reviews in Toxicology},
  volume = {0},
  pages = {1-27},
  month = {2023-08-30},
  issn = {1040-8444},
  url = {https://doi.org/10.1080/10408444.2023.2240852},
  doi = {10.1080/10408444.2023.2240852},
}