@article{1916, keywords = {disease model, Diseases, Drug Discovery, Lab-on-a-chip, Toxicology}, author = {Eric W. Esch and Anthony Bahinski and Dongeun Huh}, title = {Organs-on-chips at the frontiers of drug discovery}, abstract = {Microengineered cell culture systems are becoming sufficiently sophisticated that they can recapitulate many of the phenomena observed in tissues and organisms. Here, Huh and colleagues discuss the advances made in these 'organs-on-chips' and how they could be used in drug development, including target identification and validation, toxicity screening and stratified medicine.}, year = {2015}, journal = {Nature Reviews Drug Discovery}, volume = {14}, pages = {248-260}, month = {2015-04}, issn = {1474-1784}, url = {https://www.nature.com/articles/nrd4539}, doi = {10.1038/nrd4539}, language = {en}, }