@article{1881,
  keywords = {Animals, Blood-Brain Barrier, Drug development, Humans, Lab-On-A-Chip Devices, Neoplasms, Organ Specificity, Tissue engineering, disease modeling, Drug development, human physiology, human stem cells, microfluidics, Precision Medicine, preclinical studies, Tissue engineering},
  author = {Kacey Ronaldson-Bouchard and Gordana Vunjak-Novakovic},
  title = {Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development},
  abstract = {Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable modeling of human physiology and disease. The technology has emerged from converging advances in tissue engineering, semiconductor fabrication, and human cell sourcing. Encompassing innovations in human stem cell technology, OOCs offer a promising approach to emulate human patho/physiology in vitro, and address limitations of current cell and animal models. Here, we review the design considerations for single and multi-organ OOCs, discuss remaining challenges, and highlight the potential impact of OOCs as a fast-track opportunity for tissue engineering to advance drug development and precision medicine.},
  year = {2018},
  journal = {Cell Stem Cell},
  volume = {22},
  pages = {310-324},
  month = {2018-03-01},
  issn = {1875-9777},
  doi = {10.1016/j.stem.2018.02.011},
  language = {eng},
}