@article{1781,
  keywords = {Angiotensin-Converting Enzyme 2, Animals, Betacoronavirus, Blood Vessels, COVID-19, Chlorocebus aethiops, Coronavirus Infections, Humans, kidney, Mice, organoids, Pandemics, Peptidyl-Dipeptidase A, Pneumonia, Viral, Receptors, Virus, Recombinant Proteins, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Vero Cells, angiotensin converting enzyme 2, Blood Vessels, human organoids, kidney, severe acute respiratory syndrome coronavirus, spike glycoproteins, treatment},
  author = {Vanessa Monteil and Hyesoo Kwon and Patricia Prado and Astrid Hagelkrüys and Reiner A. Wimmer and Martin Stahl and Alexandra Leopoldi and Elena Garreta and Carmen Hurtado Del Pozo and Felipe Prosper and Juan Pablo Romero and Gerald Wirnsberger and Haibo Zhang and Arthur S. Slutsky and Ryan Conder and Nuria Montserrat and Ali Mirazimi and Josef M. Penninger},
  title = {Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2},
  abstract = {We have previously provided the first genetic evidence that angiotensin converting enzyme 2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), and ACE2 protects the lung from injury, providing a molecular explanation for the severe lung failure and death due to SARS-CoV infections. ACE2 has now also been identified as a key receptor for SARS-CoV-2 infections, and it has been proposed that inhibiting this interaction might be used in treating patients with COVID-19. However, it is not known whether human recombinant soluble ACE2 (hrsACE2) blocks growth of SARS-CoV-2. Here, we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells by a factor of 1,000-5,000. An equivalent mouse rsACE2 had no effect. We also show that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2. These data demonstrate that hrsACE2 can significantly block early stages of SARS-CoV-2 infections.},
  year = {2020},
  journal = {Cell},
  volume = {181},
  pages = {905-913.e7},
  month = {2020-05-14},
  issn = {1097-4172},
  doi = {10.1016/j.cell.2020.04.004},
  language = {eng},
}