@article{1756,
  author = {Mart M. Lamers and Tim I. Breugem and Anna Z. Mykytyn and Yiquan Wang and Nathalie Groen and Kèvin Knoops and Debby Schipper and Jelte van der Vaart and Charlotte D. Koopman and Jingshu Zhang and Douglas C. Wu and Petra B. van den Doel and Theo Bestebroer and Corine H. GeurtsvanKessel and Peter J. Peters and Mauro J. Muraro and Hans Clevers and Nicholas C. Wu and Bart L. Haagmans},
  title = {Human organoid systems reveal in vitro correlates of fitness for SARS-CoV-2 B.1.1.7},
  abstract = {A new phase of the COVID-19 pandemic has started as several SARS-CoV-2 variants are rapidly emerging globally, raising concerns for increased transmissibility. As animal models and traditional in vitro systems may fail to model key aspects of the SARS-CoV-2 replication cycle, representative in vitro systems to assess variants phenotypically are urgently needed. We found that the British variant (clade B.1.1.7), compared to an ancestral SARS-CoV-2 clade B virus, produced higher levels of infectious virus late in infection and had a higher replicative fitness in human airway, alveolar and intestinal organoid models. Our findings unveil human organoids as powerful tools to phenotype viral variants and suggest extended shedding as a correlate of fitness for SARS-CoV-2.
One-Sentence Summary British SARS-CoV-2 variant (clade B.1.1.7) infects organoids for extended time and has a higher fitness in vitro.},
  year = {2021},
  month = {2021-05-03},
  url = {https://www.biorxiv.org/content/10.1101/2021.05.03.441080v1},
  doi = {10.1101/2021.05.03.441080},
  language = {en},
}