@article{1706,
  keywords = {ACE2, COVID-19, SARS-CoV, antiviral, combination therapy},
  author = {Christopher Hopkins and Chidinma Onweni and Victoria Zambito and DeLisa Fairweather and Kathryn McCormick and Hideki Ebihara and Thomas Caulfield and Yu Shrike Zhang and W. David Freeman},
  title = {Platforms for Personalized Polytherapeutics Discovery in COVID-19},
  abstract = {The COVID-19 pandemic entered its third and most intense to date wave of infections in November 2020. This perspective article describes how combination therapies (polytherapeutics) are a needed focus for helping battle the severity of complications from SARS-CoV-2 infection. It outlines the types of systems that are needed for fast and efficient combinatorial assessment of therapeutic candidates. Proposed are micro-physiological systems using human iPSC as a format for tissue-specific modeling of infection, the use of gene-humanized zebrafish and C. elegans for combinatorial drug screens due to the animals being addressable in liquid multi-well formats, and the use of engineered pseudo-typing systems to safely model infection in the transgenic animals and engineered tissue systems.},
  year = {2021},
  journal = {Journal of Molecular Biology},
  volume = {433},
  pages = {166945},
  month = {2021-05-14},
  issn = {0022-2836},
  url = {https://www.sciencedirect.com/science/article/pii/S0022283621001467},
  doi = {10.1016/j.jmb.2021.166945},
  language = {en},
}