@article{1696,
  author = {Jenna M. Kastenschmidt and Suhas Sureshchandra and Aarti Jain and Jenny E. Hernandez-Davies and Rafael De Assis and Zachary W. Wagoner and Andrew M. Sorn and Mahina Tabassum Mitul and Aviv I. Benchorin and Elizabeth Levendosky and Gurpreet Ahuja and Qiu Zhong and Douglas Trask and Jacob Boeckmann and Rie Nakajima and Algimantas Jasinskas and Naresha Saligrama and D. Huw Davies and Lisa E. Wagar},
  title = {Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids},
  abstract = {Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To advance informed vaccine design, it is critical that we understand the cellular dynamics underlying responses to different antigen formats. Here, we sought to understand how antigen-specific B and T cells were activated and participated in adaptive immune responses within the mucosal site. Using a human tonsil organoid model, we tracked the differentiation and kinetics of the adaptive immune response to influenza vaccine and virus modalities. Each antigen format elicited distinct B and T cell responses, including differences in their magnitude, diversity, phenotype, function, and breadth. These differences culminated in substantial changes in the corresponding antibody response. A major source of antigen format-related variability was the ability to recruit naive vs. memory B and T cells to the response. These findings have important implications for vaccine design and the generation of protective immune responses in the upper respiratory tract.},
  year = {7},
  journal = {Immunity},
  pages = {S1074761323002765},
  month = {7/2023},
  issn = {10747613},
  url = {https://linkinghub.elsevier.com/retrieve/pii/S1074761323002765},
  doi = {10.1016/j.immuni.2023.06.019},
  language = {en},
}