@article{1506,
  keywords = {Allergy and Immunology, Biomedical Research, Cell Differentiation, Epithelial Cells, Epithelium, Fetal Development, Homeostasis, Humans, Infections, Lymphopoiesis, organoids, Regeneration, T-Lymphocytes, Thymus Gland, Tumor Microenvironment},
  author = {Yotam E. Bar-Ephraim and Kai Kretzschmar and Hans Clevers},
  title = {Organoids in immunological research},
  abstract = {Much of our knowledge regarding the interactions between epithelial tissues and the immune system has been gathered from animal models and co-cultures with cell lines. However, unique features of human cells cannot be modelled in mice, and cell lines are often transformed or genetically immortalized. Organoid technology has emerged as a powerful tool to maintain epithelial cells in a near-native state. In this Review, we discuss how organoids are being used in immunological research to understand the role of epithelial cell-immune cell interactions in tissue development and homeostasis, as well as in diseases such as cancer.},
  year = {2020},
  journal = {Nature Reviews. Immunology},
  volume = {20},
  pages = {279-293},
  month = {2020-05},
  issn = {1474-1741},
  doi = {10.1038/s41577-019-0248-y},
  language = {eng},
}