@article{1011,
  keywords = {3-D tissue models, lung physiology, mechanobiology, microphysiological system, organ chip},
  author = {Haiqing Bai and Donald E. Ingber},
  title = {What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?},
  abstract = {The intertwined relationship between structure and function has been key to understanding human organ physiology and disease pathogenesis. An organ-on-a-chip (organ chip) is a bioengineered microfluidic cell culture device lined by living cells and tissues that recapitulates organ-level functions in vitro. This is accomplished by recreating organ-specific tissue-tissue interfaces and microenvironmental biochemical and mechanical cues while providing dynamic perfusion through endothelium-lined vascular channels. In this review, we discuss how this emerging technology has contributed to the understanding of human lung structure-function relationships at the cell, tissue, and organ levels.},
  year = {2022},
  journal = {Physiology},
  volume = {37},
  pages = {242-252},
  month = {2022-09},
  issn = {1548-9213},
  url = {https://journals.physiology.org/doi/abs/10.1152/physiol.00012.2022},
  doi = {10.1152/physiol.00012.2022},
}